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Integrating Clinical Trials and Practice
May8, 2025
JulienDreyfus,MD, PhD1; DavidMessika-Zeitoun,MD, PhD2,3
Author Affiliations Article Information
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1Cardiology Department, Centre Cardiologique du Nord, Saint-Denis, France
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2Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
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3School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
JAMA. Published online May 8, 2025. doi:10.1001/jama.2025.5391
- Original Investigation Transcatheter Edge-to-Edge Repair for Tricuspid Regurgitation
ErwanDonal,MD, PhD; JulienDreyfus,MD, PhD; GuillaumeLeurent,MD; AugustinCoisne,MD, PhD; Pierre-YvesLeroux,MD; AnneGanivet,MSc; CatherineSportouch,MD, PhD; YoanLavie-Badie,MD; PatriceGuerin,MD, PhD; FrédéricRouleau,MD; ChristelleDiakov,MD; Janvan der Heyden,MD; StéphaneLafitte,MD, PhD; Jean-FrançoisObadia,MD, PhD; MohammedNejjari,MD; NicoleKaram,MD, PhD; AnneBernard,MD, PhD; AntoinetteNeylon,MD; RomainPierrard,MD; DidierTchetche,MD; SaidGhostine,MD; GregoryDucrocq,MD, PhD; ThiziriSi Moussi,MD; AntoineJeu,MD; MarcelPeltier,MD, PhD; BernardCosyns,MD, PhD; YvanLe Dolley,MD; GilbertHabib,MD, PhD; VincentAuffret,MD, PhD; FlorentLe Ven,MD, PhD; FrançoisPicard,MD; NicolasPiriou,MD; ThierryLaperche,MD; ElenaGalli,MD, PhD; SabinaIstratoaie,MD, PhD; JeromeJouan,MD, PhD; GuillaumeBonnet,MD; Pascalde Groote,MD, PhD; AmedeoAnselmi,MD, PhD; Jean-NoelTrochu,MD, PhD; EmmanuelOger,MD, PhD; Tri-Fr Investigators
JAMA
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Tricuspid regurgitation (TR) is a highly prevalent condition, particularly in the aging population, and has gained significant attention over the past decade with the advent of transcatheter tricuspid valve interventions. This renewed interest has led to significant progress in understanding the mechanisms of TR, including the introduction of a new classification (primary, secondary, and lead related), advancements in imaging and TR quantification with the refinement of tricuspid valve anatomy nomenclature and grading scale, and the development of dedicated prognostic risk scores. The role of less-invasive therapeutic options in driving these advances should not be underestimated, including their influence on the development of new classifications that favor the demonstration of positive outcomes from these therapies.
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Dreyfus J, Messika-Zeitoun D. Management of Tricuspid Regurgitation—What’s Next? JAMA. Published online May 08, 2025. doi:10.1001/jama.2025.5391
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